Setup man: The setup of a new device is perhaps where the distinction is most apparent. Whereas previous iOS devices would welcome you with the all-too-familiar instruction to plug them into a computer running iTunes, iOS devices now display a friendly welcome message—much like when you set up a new Mac.
It's a pretty straightforward process, and one that even a technological neophyte shouldn't have too much trouble with. Apple provides help links for most screens, explaining what a given technology is and why a person might want to use it. Much kudos in particular to the company for making Find My iPhone a part of every iOS device setup process. Having known a number of people who have lost their devices, or had them pilfered by nefarious wrongdoers, this is a feature that can genuinely help people—if they set it up. And now, thanks to iCloud, it's available to all iOS device users for free.
Mind the Gap: Apple has also taken this opportunity to fill in numerous gaps in functionality that used to send one scurrying for their computer. For example, you can now add photo albums on the iPhone. You can create playlists. You can delete songs from your Music library (though, woe still betide you if you want to add anything to that library without going through Apple's prescribed methods). And, joy of joys, you can now update an iOS device's software right from the device itself, over the air—a capability that has been deployed by many of Apple's competitors in a decidedly hit-or-miss fashion.