-- Don't use it on a machine running Vista or Windows XP. Microsoft originally said this would be ok, but now the recommendation is Windows 7 or higher (i.e. Windows 8).
-- Do not pull the thumb drive from a running machine. If it does get pulled out accidentally, reinsert the drive into the same USB port within 60 seconds to resume where you left off. Otherwise you will have to start your session over.
-- You must connect the USB thumb drive directly into the PC. Do not connect the Windows To Go drive to a USB hub.
Shane O'Neill covers Microsoft, Windows, Operating Systems, Productivity Apps and Online Services for CIO.com. Follow Shane on Twitter @smoneill. Follow everything from CIO.com on Twitter @CIOonline and on Facebook. Email Shane at email@example.com