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I like the Q&A in the linked article: "Do registry cleaners work? Maybe." Which, of course, implies maybe not as well.
I have seen so many PCs screwed up by people using registry cleaners who weren't careful, or perhaps didn't know what they were doing. I would tread carefully with registry cleaners if I used them at all. I whole-heartedly agree with the article that you should make a back up before using a registry cleaner, if you decide to go that route.
Personally, I take the view that you are generally better off leaving the registry alone. Sure there are going to be some unused settings, but it doesn't make much of a difference. You are unlikely to see much, if any improvement in a computer's speed from messing around with the registry, and there is the real risk of screwing up and removing something needed by the OS.