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I personally have a mild colorblindness issue, and certainly too much or too little contrast can cause readability issues. You have to also keep in mind that there are a wide variety of displays, lighting conditions, user settings, etc., so you will never be perfect for 100% of viewers. Even so, I like to use a tool that measures color and brightness differential. It's been around for years, so it's not the slickest, but it works.