The more tabs you have open and extensions running, the more memory Chrome needs. If you find the browser experience excruciatingly slow, close the tabs and disable the extensions that are using up the most memory. Here's how to find them.
All you have to do is type in chrome://memory-redirect in the Chrome omnibox to get to a detailed memory page. Chrome will show you not only how much memory it is using, but also how much memory is being used by individual tabs and extensions. Interestingly enough, if you have another browser running (e.g., Firefox, Internet Explorer, or Safari), you'll be able to compare memory usage for that as well.
Once you've found the most memory-hungry tabs and extensions, you can selectively close them and give Chrome a nice performance boost.
[via How-To Geek]
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