Our department which currently runs a 1000+ core machine and 2500+ core machine for MD simulations is still waiting on jumping onto the Amazon/Cloud bandwagon mostly because it's still not cheaper than owning a cluster for a few years.
michaelgrosner on news.ycombinator.com
If the calculations were so parallel, and it took 50k cores 3hrs, wouldn't it take their home cluster of 1.5k cores ~100hrs (a holiday weekend)?
FirsbeeFreek on arstechnica.com
Long row to hoe
Having been privy to the state-of-the-art projects in a lab with a ~5,000 node cluster it was still disappointing to see how rough the whole cell modeling approaches were.
jboggan on news.ycombinator.com
What needs to be done is a lot of slow, messy "wet bench" biology.