Why one virus engine is not enough
Multiple virus engines are needed to reduce time lag between virus outbreak and signature update - by GFI Software
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Multiple Scan Engines
This article brings to mind Microsoft's Forefront product. The New Jersey company they acquired to add to their security product permitted you to run multiple scan engines to protect the exchange server.A number of security appliances have multiple scan engines. Several years ago, Trend Micro had the "named" scan engine in a 3rd party appliance and Kaspersky's scan engine was so far under the head that it did not appear on data sheets.
An issue not really addressed in the article - do you run the engines in parallel? Does everything get tested by both? Is the testing random between the two (or more engines) with an equal or unequal weighting? Microsoft's acquisition (I haven't looked what Microsoft does with respect to this) permitted you to tweak the percentages.
And of course - what is the effect of multiple scan engines on performance?