Most programs don't prioritize email; it just shows up, with equal weight given to emergencies and uninteresting retail pitches. Sanebox shows only your most important email, shunting lower-priority missives to folders such as "SaneArchive" and "SaneLater." This cloud-based service works with any IMAP email, and it's surprisingly good at guessing what you want to see. It's number 88 on our list.
rtpMIDI (music software)
Yes, this choice is a little esoteric, as it's designed for musicians. If you fall into that category, this software is worthy of your attention. Updated in September, rtpMIDI lets you control MIDI (Musical Instrument Digital Interface) devices (including other computers running MIDI software) with a networked PC or even an iPad.