OK, so what else can you do if you stick with Windows?
Manky highly recommends having nothing to do with files from outside your company or home unless you know that they're from a trusted source. He said, "Beware of poisoned documents: PDF, XLS and DOC files are routinely exploited to drop botnet binaries."
Adobe PDFs, in particular, are being abused by both botnet users and more run of the mill malware authors. Worst still, few people seem to be updating their PDF readers even as more and more attacks using PDFs appear. While updating your software isn't any guarantee of safety, not updating it does guarantee that your chances of getting into trouble have increased.
Still, as Wang said, "In a business setting the addition of Web filtering can go a long way towards keeping bots away from your PCs. The Web is the principal means of distribution for malicious software so blocking access to known sources of malware and scanning content from everywhere else is a must for any security setup."
A good firewall can also help. While a firewall won't stop a botnet infection per se, it can block the network ports used by botnet controllers to point and shot the botnet software.
Unfortunately, while botnets used to use such relatively obscure ports as IRC's (Internet Relay Chat) TCP 6660-6669, which were easy to block. "Now," as Manky noted, "they have evolved to use common ports such as HTTP (80) and HTTPS (443) but with common protocols, that are encrypted with their own algorithms to evade detection. Peer-to-peer networks have also been established to make the botnet more bullet-proof to take down."
What it all boils down to is that there's no easy way to stop botnets. All you can do is practice all the usual PC security steps, keep your firewall guard up, and keep a close eye on your network traffic logs for any unusual activity. And, realize that even that may not be enough and you may have to eventually repair your Windows systems if you discover that your friendly PC is now under the control of an enemy.
Good luck. We all need it.