If you encounter a DVD with 99 titles of almost the same length, you've run into a copy-protection scheme meant to thwart ripping. In that case, launch Apple's DVD Player application, navigate to the main feature, choose Go -> Title from the menu bar, and find the title with a check mark next to it. Choose that title in HandBrake and continue.
If there are several items you want to convert--all the episodes on a TV show DVD, for example--you can select one, give it a unique name in the File area, click the Add To Queue button, and then repeat the process for each item until they've all been added to the encoding queue (you'll want to adjust your encoding settings prior to adding the items to the queue, however, which I'll discuss in the next step).
[Note that DVD ripping is a constant cat-and-mouse game, with content providers regularly updating their copy-protection schemes to prevent copying, and HandBrake/VLC trying to provide access to the latest discs. Which is a long way of saying that HandBrake may not work with every DVD. If all else fails, you may need to spend money on a different DVD-ripping application for better results.]
Step Three: Choose a preset
Now that you've selected the title to rip, you'll need to choose your encoding settings based on the device(s) on which you plan to view the content. Although you can tweak every aspect of encoding, HandBrake includes handy presets that make it much easier.
If the Presets Drawer isn't already open, click on the Toggle Presets button at the top of the HandBrake window (or press command-T). In the drawer, you'll see three sets of presets: Apple, Regular, and Legacy. In most cases, you can just focus your attention on the Apple section. There you'll find Universal, iPod, iPhone & iPod Touch, iPhone 4, iPad, AppleTV, and AppleTV 2.
If you want to watch your movie on the latest iPhone, for example, choose iPhone 4 for the best quality settings that will work on that device. The same goes for other devices, based on their playback restrictions. The Universal preset is helpful if you want a file that will work on all current Apple devices.
If you're ripping TV show episodes, you'll have to pick your settings for each file before adding it to the queue. To speed up the process, you can set a preset as your default. Highlight the preset you want, then at the bottom of the Preset Drawer, click the gear icon and choose Make Default from the drop-down menu.
Step Four: Tweak your settings
Once you've picked your preset, there are a few settings you might want to pay extra attention to, depending on your specific needs.